BriteSMART® Restores Levels of Vital Nutrients to... Improve Learning and Recall Enhance Focus and Concentration Boost Mental Energy, Clarity & Acuity Contains 90 easy-to-swallow rapidly absorbed tablets

BriteSMART® Contains a proprietary blend of natural, 
clinically proven ingredients that help to optimize brain function, 
improve memory, enhance mental focus and increase brain energy.

BriteSMART® Produces fast results with its unique "triple-action" formula that rapidly boosts brain energy by raising the brain's glucose, oxygen and neurotransmitter levels.

BriteSMART®  Restores and replenishes the vital nutrients that age 
and lifestyle take away!

BriteSHIELD Defends Your Brain Against Neurotoxins to... Provide Anti-oxidants to protect your Brain Detoxify your Brain Promote Brain Health and Longevity Contains 60 easy-to-swallow rapidly absorbed tablets

BriteSHIELD® is a breakthrough nutritional supplement that can significantly protect your brain against the ravages of aging and lifestyle.

BriteSHIELD® contains a proprietary blend of safe, natural and effective ingredients clinically shown to help defend brain cells against free radicals, inflammation and other neurotoxins, e.g., mercury, that contribute to the aging process.

BriteSHIELD® combined with BriteSMART® can significantly enhance mood, memory and mental performance while optimizing brain protection against the primary causes of accelerated cognitive decline and dysfunction.

Nutraceutical Selection Criteria

Pharmaceutical Grade FDA Compliant Manufacturing Clinical Study Validation Proven Brain Ingredients (not a multi-vitamin) Clinically Effective Ingredient Amounts Neurogenetive & Antioxidant Capability Total Brain Program

Optimizes brain function Increases cerebral blood circulation Increases brain energy Supports healthy brain cell communication Improves memory, focus and concentration Protects against the risk of cell damage from free radicals and toxins Antioxidizes to support anti-aging of the brain Promotes internal detoxification system

Brite Age has turned to the #1 Expert in America today when it comes to solving this problem you and millions of other people, just like you, are encountering every day.

They turned to Joshua Reynolds, Inventor, Scientist and Nutritional Formulator to create a solution to the aging brain you and everyone you know and love is facing.

Joshua Reynolds
Brain Nutrition Expert, Formulator & Scientist for BriteAGE

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Natural Supplements

Choose from the list below for a complete list of references for each brain healthy natural supplement:

Ceretrophin® (proprietary blend of the following 6 natural supplements)

Biotin is a member of the B-vitamin family, is an essential nutrient in human nutrition. It is involved in the biosynthesis of fatty acids, gluconeogenesis, energy production, and the metabolism of the branched-chain amino acids (L-leucine, L-isoleucine, L-valine). Biotin improves glucose tolerance and decreases insulin resistance, both healthy factors for the brain. Biotin levels may be depleted by alpha lipoic acid intake, and therefore has been added to replenish this possible depletion, as well as boost glucose metabolism and balance.

References

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Acetyl-L-Carnitine (ALC) is perhaps the one true miracle molecule, especially for your brain (and heart). ALC is naturally found in the brain and body. Its main dietary source is red meat, although you’d have to eat over 50lbs. a day to get enough for improved mental performance. ALC has multiple roles in the protection, preservation and performance of your brain cells. It increases brain blood flow as well as the synthesis and utilization of acetylcholine (ACh), a key neurotransmitter for mental clarity, memory and focus. It improves the energy output of your mitochondria, helps stabilize the neural membrane, and protects both from free radical damage. ALC has been shown to protect the brain even after a head injury or stroke, and it helps accelerate the healing of damaged neurons. It’s believed to help remove a serious brain damaging plaque, a dark pigment called lipofuscin. ALC also increases levels of glutathione, perhaps the brain’s most important anti-oxidant. ALC has also been shown to increase levels of nerve growth factor thus stimulating the growth of new neurons, synapses and their interconnecting “wires”, called axons and dendrites. In fact, ALC appears to rejuvenate the brain and, especially when combined with alpha lipoic acid (see below) it may significantly slow brain aging, especially in the mitochondria. And, it helps protect the brain and liver from the harmful by-products of alcohol.

Dozens of clinical studies have demonstrated ALC’s powerful effect on improving mental clarity, focus and memory, in reducing depression, and boosting processing speed and cognitive function, in both normal and cognitively impaired individuals.

References

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R-Alpha Lipoic Acid (R-ALA) is the R form of ALA, and is believed to be (perhaps significantly) more biologically active than the S form. Normal alpha lipoic acid ( ALA) is racemic meaning it contains 50% the R form and 50% the S form. R-ALA is a powerful antioxidant at the mitochondrial level where its ability to tame the fires and free radicals of the oxidative, energy generating process is highly essential to protect the mitochondria from burn out. ALA revitalizes, or recycles other neuro-protective, anti-oxidant agents, such as Vitamins C and E, and CoQ10. It increases brain levels of glutathione, an important antioxidant, brain protector and immune system booster. ALA also improves blood sugar balance, lowers insulin resistance, and reduces the glycation of proteins, or AGE plaque formation. It has been shown to improve memory and actually reverse neuropathy. ALA, when combined with acetyl-l-carnitine has shown remarkable synergistic effects in slowing down brain aging at the mitochondrial level.

References

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Rhodiola (RHO) is an herbal supplement that appears to buffer the brain against the negative effects of stress (cortisol) and other environmanetal, physical and biochemical stressors such as, work fatigue. RHO is especially effective in improving mental and physical mental performance in demanding situations. Once revealed as the secret behind the phenomenal strength and endurance feats of Bulgarian and Russian Olympic athletes, this high-altitude mountain plant is popular as an adaptogenic agent, specifically during times of stress or high-energy mental and physical performance demands. Actual studies in Europe have shown that it improved mental performance in medical students and pilots under stress. RHO increases several neurotransmitters including dopamine, which regulates focus (attention) and moods, and norepenephrine, which regulates alertness and long term memory formation.

References

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Vinpocetine (VIN) is a natural extract of the beautiful periwinkle flower, vinca minor. It increases cerebral vascular blood flow, thus enhancing the flow of nutrients, oxygen, glucose and neurotransmitter substrates, e.g., choline to the brain. VIN has been shown to improve memory and brain processing speed. It also increases brain glucose metabolism and increases the mitochondria’s generation ATP, which improves brain energy as well as mood, memory and other mental functions. It is also a powerful anti-oxidant, and neuro-protective agent that has been shown to protect brain cells against the chronic age-related reduction in oxygen levels and the acute and sudden loss of oxygen, such as after a stroke. VIN also protects the brain from imbalances in calcium regulation, or calcium overload which is another major cause of cognitive decline and brain dysfunction with age.

References

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Huperzine A (HUP) is derived from Chinese Club Moss (Huperia serrata). It’s a natural acetylcholinesterase (AChE) inhibitor. AChE is the enzyme that destroys acetylcholine in the synapse before it’s effectively used to communicate your thoughts, feelings and memories. HUP helps keep your acetylcholine levels up, so your synapses fire fast and efficiently. HUP has been shown to improve memory, protect brain cells both from free radical and glutamate “excitotoxicity”, a highly damaging condition found in accelerated brain aging and Alzheimer’s. HUP also stimulates the acetylcholine receptors making them more sensitive to existing levels of ACh. HUP may also act as a brain metabolic enhancer.

References

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Ceraprotectin® (proprietary blend of the following 7 natural supplements)

R-Alpha Lipoic Acid (R-ALA) is the R form of ALA, and is believed to be (perhaps significantly) more biologically active than the S form. Normal alpha lipoic acid ( ALA) is racemic meaning it contains 50% the R form and 50% the S form. R-ALA is a powerful antioxidant at the mitochondrial level where its ability to tame the fires and free radicals of the oxidative, energy generating process is highly essential to protect the mitochondria from burn out. ALA revitalizes, or recycles other neuro-protective, anti-oxidant agents, such as Vitamins C and E, and CoQ10. It increases brain levels of glutathione, an important antioxidant, brain protector and immune system booster. ALA also improves blood sugar balance, lowers insulin resistance, and reduces the glycation of proteins, or AGE plaque formation. It has been shown to improve memory and actually reverse neuropathy. ALA, when combined with acetyl-l-carnitine has shown remarkable synergistic effects in slowing down brain aging at the mitochondrial level.

References

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N-Acetyl-Cysteine (NAC): an amino acid with powerful neuroprotective and anti-oxidant actions, even down at the mitochondrial level. NAC is a precursor of glutathione, one of the most powerful endogenous immune enhancers. NAC and glutathione fight brain inflammation as well as free radicals. NAC also chelates heavy metals, such as lead and mercury, lightening their toxic load on the brain. NAC lowers brain damaging homocysteine levels. Some studies suggest that combining NAC with other anti-oxidants and the B vitamins significantly reduces the risk for developing Alzheimer’s later in life. In fact, NAC has been shown to improve cognitive function in a group with elevated homocysteine, an acknowledged brain toxin.

References

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Quercetin is a dietary flavonoid found in many plants, including tea, apple, onion, ginkgo biloba and citrus.

Quercetin forms the "backbone" for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. In studies, Quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several stages and processes of inflammation. In addition, it exerts potent antioxidant activity and boosts the effectiveness of vitamin C.

Quercetin has antioxidant, anti-inflammatory, nitric oxide inhibitor, and tyrosine kinase inhibitor (leading to inhibition of the division and growth of T-cells and some cancer cells) activity. The anti-inflammatory effects of quercetin appear to be due to inhibition of the production and activity of leukotrienes and prostaglandins, and inhibition of histamine. Quercetin also appears to reduce capillary fragility.

Quercetin’s broad spectrum anti-oxidant and anti-inflammatory actions make it one of the best cytoprotective and neuroprotective molecules found in nature.

References

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Resveratrol (RES) is a flavonoid found in more than 70 plants including Asian herbs, grapevine, grapes, peanuts and berries. Recent data suggest that nutritional intake of resveratrol may contribute to the "French paradox", the unexpectedly low cardiovascular morbidity in the Mediterranean population. There is increasing evidence that resveratrol exerts multifaceted anti-oxidant and anti-inflammatory effects in the brain. Importantly, resveratrol was reported to slow aging and increase lifespan in simple organisms and has been suggested as a potential calorie restriction mimetic and anti-aging nutrient.

RES has been found to protect the brain against the neurotoxic and degenerative effects of beta amyloid (aka Abeta), the neurotoxic protein that builds up in the brain tissue of people with Alzheimer's disease and kill neurons.

One of Resveratrol’s most potent effects is its ability to block Nuclear Factor kappaBeta. NF-kB as an important contributor to the destructive power of amyloid beta plaques in the brain. RES also reduces destructive inflammation in the microglial, part of the white matter which act’s as the brain’s immune system.

Resveratrol’s demonstrated anti-aging effects derive from its apparent ability to activate important sirtuins, especially Sir2 enzymes which have been shown to promote cell survival and longevity in lower organisms.

References

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MethylCobalamin (Vitamin B12) is a co-enzyme, methyl form of Vitamin B-12 that is more specific to the central nervous system and brain than the standard, supplemental synthetic form of B-12, cyancobalamin.

Vitamin B12 is used orally for anemia, aging, improving concentration, mood elevation, boosting energy, and raising energy levels.

The methylcobalamin form of vitamin B12 is required in one of the pathways for homocysteine (Hcy) metabolism. Elevated Hcy levels have been implicated in accelerated cognitive decline, memory loss, and Alzheimer’s. METHC plus vitamin B-6 and folic acid can lower Hcy and improve brain health and cognitive performance.

METHC has other unique properties. For one it’s a neuroprotective agent which means it can help neutralize the brain damaging effects of certain neurotoxins such as, calciumoverload in the brain cells. It also helps accelerate the repair of damaged neural tissue which takes place daily as a result of aging, lifestyle excesses, free radicals and oxidative stress, inflammation and calcium overload.

Methylcobalamin may even regenerate brain cell connections called axons. These, as well as dendrites are the “wires, or cables” that enable neurons to communicate with each other. METHC also supports synthesis of the myelin sheath which is the vital electrical insulation of the brain’s axons. This helps the brain communicate your perceptions, thoughts, memories, decisions and emotions faster and more efficiently throughout more of the brain.

Vitamin B12 is involved in fat and carbohydrate metabolism and protein synthesis. Vitamin B12 is essential for folate utilization, and its absence results in a functional folate deficiency. Vitamin B-12 deficiency may be a predominant cause of, or at least major contributor to cognitive dysfunction and memory loss, especially with vegetarians and seniors. For one, as we age the intestinal absorption of B-12 from foods is reduced. Secondly, older people and of course, vegetarians tend to eat less animal protein which is a primary source of B-12.

Some researchers think that vitamin B12 supplements could help symptoms of chronic fatigue syndrome by correcting red blood cell abnormalities and improving oxygen delivery to tissues. The methylcobalamin form of vitamin B12 might also influence melatonin levels. Methylcobalamin seems to improve alertness and reduce sleep time in humans with normal sleep patterns, possibly due to effects on melatonin.

References

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Curcumin (CUR): The active polyphenol compound in the bright yellowish orange spice, Turmeric, CUR is a powerful COX-2 inhibitor. It also reduces brain inflammation via other pathways such as, LOX-5 as well as highly damaging NOS (nitric oxide) based peroxynitrites. CUR is also a powerful anti-oxidant and neuro-protective agent. Perhaps most remarkably it has demonstrated the ability to reduce and prevent the formation of the telltale Alzheimer’s plaques known as beta amyloid, or Abeta. In fact, studies even revealed that CUR can reduce the existing plaque burden of Abeta.

References

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Bioperine is the brand name for a Black Pepper fruit extract (98% piperine) that has been shown to enhance the bioavailability of certain nutrients including the Curcumin and possibly Quercetin found in BriteSHIELD®.

Product Safety and Instructions

Both formulas contain natural ingredients that have been in the marketplace for over 20 years.
The most common side effects of ingredients in BriteSMART® and BriteSHIELD® are:

• Nausea

• Upset stomach

• Headaches

• Sleep loss

These side effects may affect a small percentage (3%) of users depending upon a broad variety of pre-disposing factors, including individual sensitivities, food present in the stomach, medications and/or other supplements taken concomitantly, stress levels, proclivity towards migraine headaches, stomach ulcer, and others.

Unless cleared by a physician, BriteSMART® and BriteSHIELD® should not be used by individuals with a diagnosis of arrhythmias, schizophrenia, bi-polar disorder or manic disorder, epilepsy or seizure disorders, hemophilia, migraines or by individuals using drugs categorized as anti-psychotics, anti-dementia (cholinesterase inhibitors, NMDA antagonists), anti-coagulants such as acenocoumarol, clopidogrel (Plavix™), dalteparin (Fragmin™), enoxaparin (Lovenox™), heparin, ticlopidine (Ticlid™), and warfarin (coumadin), anti-platelet aggregation, coagulants and MAO Inhibitor agents.

Individuals taking prescription drugs containing beta blockers for heart conditions should be aware that Rhodiola, one of the six ingredients in BriteSMART® , may affect beta blockers and thereby possibly stimulating heart rate. Women who are pregnant or nursing should not take BriteSMART® and BriteSHIELD® . If anyone has an existing medical condition(s) and/or is taking medications such as prescription drugs, a physician should be consulted prior to taking BriteSMART® and BriteSHIELD® .